Selected Publications
2024
Peysakhovich B., Zhu O., Tetrick, S.M., Shirhatti V., Silva A.A., Li S., Ibos G., Rosen M.C., Johnston W.J., and Freedman D.J.
Primate superior colliculus is causally engaged in abstract higher-order cognition.
Nature Neuroscience, in press. bioRxiv version
2023
Johnston W.J. and Freedman D.J.
Redundant representations are reuired to disambiguate simultaneously presented complex stimuli.
PLoS Computational Biology, 19: e1011327.
Goudar V., Peysakhovich B., Freedman D.J., Buffalo E.A., and Wang X.J.
Schema formation in a neural population subspace underlies learning-to-learn in flexible sensorimotor problem-solving.
Nature Neuroscience, 25: 879-890.
Tilley M. J., Miller M., and Freedman, D.J. Artificial neuronal ensembles with learned context dependent gating.
In Proceedings of the International Conference on Learning Representations.
Latimer K.W. and Freedman D.J.
Low-dimensional encoding of decisions in parietal cortex reflects long-term training history.
Nature Communications, 14: 1010.
2022
Zhou Y., Mohan K., and Freedman D.J.
Abstract Encoding of Categorical Decisions in Medial Superior Temporal and Lateral Intraparietal Cortices
Journal of Neuroscience, 10.1523/JNEUROSCI.0017-22.2022.
2021
Mohan K., Zhu O., and Freedman D.J.
Interaction between neuronal encoding and population dynamics during categorization task switching in parietal cortex
Neuron, 109: 700-712.
Zhou Y.*, Rosen M.C.*, Swaminathan S.K., Masse N.Y., Zhu O., and Freedman D.J.
Distributed functions of prefrontal and parietal cortices during sequential categorical decisions.
eLife, 10: e58782.
2020
Mansouri F.A., Freedman D.J., Buckley M.J.
Emergence of abstract rules in the primate brain
Nature Reviews Neuroscience, 21: 595-610.
Cone J.J., Bade M.L., Masse N.Y., Page E.A., Freedman D.J. and Maunsell J.H.
Mice Preferentially Use Increases in Cerebral Cortex Spiking to Detect Changes in Visual Stimuli
Journal of Neuroscience, 40: 7902-7920.
Johnston W.J., Palmer S.E. and Freedman D.J.
Nonlinear mixed selectivity supports reliable neural computation
PLoS Computational Biology, 16: e1007544.
Masse N.Y., Rosen M.C. and Freedman D.J.
Reevaluating the Role of Persistent Neural Activity in Short-Term Memory
Trends in Cognitive Sciences, 24: 242-258.
2019
Zhou Y. and Freedman D.J.
Posterior Parietal Cortex Plays a Causal Role in Perceptual and Categorical Decisions
Science, 365: 180-185.
UChicago Press Release
Masse N.Y., Yang G.R., Song H.F., Wang X.J., and Freedman, D.J.
Circuit mechanisms for the maintenance and manipulation of information in working memory.
Nature Neuroscience 22: 1159-1167. UChicago Press Release
2018
Masse N.Y., Grant G.D., and Freedman, D.J.
Alleviating catastrophic forgetting using context-dependent gating and synaptic stabilization.
PNAS 115: 11103-11105. UChicago Press Release
Freedman D.J. and Ibos G.
An integrative framework for sensory, motor, and cognitive functions of posterior parietal cortex.
Neuron, 97: 1219-1234.
2017
Masse N.Y., Hodnefield J.M., and Freedman D.J.
Mnemonic encoding and cortical organization in parietal and prefrontal cortices.
Journal of Neuroscience, 37: 6098-6112.
Ibos G. and Freedman D.J.
Sequential sensory and decision processing in posterior parietal cortex.
eLife, 2017;6:e23743.
Chaisangmongkon W., Swaminathan S.K., Freedman D.J., and Wang X.J.
Computing by robust transience: How the fronto-parietal network performs sequential category-based decisions.
Neuron, 93: 6, 1504-1517.
2016
Freedman D.J. and Pesaran B.
Where are perceptual decisions made in the brain?
Trends in Neurosciences, 39: 642-644.
Ibos G. and Freedman D.J.
Interaction Between Spatial and Feature Attention in Posterior Parietal Cortex
Neuron, 91: 931-943.
Freedman D.J. and Assad J.A.
Neuronal Mechanisms of Visual Categorization: An Abstract View on Decision Making
Annual Review of Neuroscience, 39, 2016.
Sarma A., Masse N.Y., Wang X.J., and Freedman D.J.
Task Specific versus Generalized Mnemonic Representations in Parietal and Prefrontal Cortices.
Nature Neuroscience, 19: 143-149, 2016. News and Views by Birman and Gardner
2015
Lim S., McKee J.L., Woloszyn L., Amit Y., Freedman D.J., Sheinberg D.L., and Brunel N.
Inferring Learning Rules from Distribution of Firing Rates in Cortical Neurons.
Nature Neuroscience, 18: 1804-10, 2015. News and Views by Senn and Sacramento
Choice-Correlated Activity Fluctuations Underlie Learning of Neuronal Category Representations
Engel T.A., Chaisangmongkon W., Freedman D.J., and Wang X.J.
Nature Communications, 6: 6454, 2015.
2014
Task Dependence of Visual and Category Representations in Prefrontal and Inferior Temporal Cortices
McKee J.L., Riesenhuber M., Miller E.K., and Freedman D.J.
Journal of Neuroscience, 34: 16065-16075, 2014.
A Hierarchy of Intrinsic Timescales Across Primate Cortex
Murray J.D., Bernacchia A., Freedman D.J., Romo R., Wallis J.D., Cai X., Padoa-Schioppa C., Pasternak T., Seo, H., Lee D., and Wang X.J.
Nature Neuroscience, 17: 1661-1663, 2014.
Dynamic Integration of Task-Relevant Visual Features in Posterior Parietal Cortex
Ibos G. and Freedman D.J.
Neuron 83: 1468-1480, 2014. University of Chicago Press Release
2013
A Comparison of Lateral and Medial Intraparietal Areas During a Visual Categorization Task
Swaminathan S.K.*, Masse N.Y.*, and Freedman D.J.
Journal of Neuroscience, 33: 13157-13170, 2013. *co-first authorship
Independent Category and Spatial Encoding in Parietal Cortex
Rishel C.A., Huang G., and Freedman D.J.
Neuron, 77: 969-979, 2013.
Chicago Tribune story, University of Chicago Press Release
Biased Associative Representations in Parietal Cortex
Fitzgerald J.K., Freedman D.J., Fanini A., Bennur S., Gold J.I., and Assad J.A.
Neuron, 77: 180-191, 2013.
Neuron Perspective by Matthew Chafee
High-Performance Execution of Psychophysical Tasks With Complex Visual Stimuli in MATLAB
Asaad W.F., Santhanam N., McClellan S.M., and Freedman D.J.
Journal of Neurophysiology, 109: 249-260, 2013.
2012
Visual Categorization and the Parietal Cortex
Fitzgerald J.K., Swaminathan S.K., and Freedman D.J.
Frontiers in Integrative Neuroscience, 6:18, 2012.
Familiarity Breeds Plasticity: Distinct Effects of Experience on Putative Excitatory and Inhibitory Neurons in Inferior Temporal Cortex
Freedman D.J.
Neuron, 74: 8-11, 2012. (Preview)
Preferential Encoding of Visual Categories in Parietal Cortex Compared with Prefrontal Cortex
Swaminathan S.K. and Freedman D.J.
Nature Neuroscience, 15: 315-320, 2012.
University of Chicago Press Release about this work
2011
Generalized Associative Representations in Parietal Cortex
Fitzgerald J.K., Freedman D.J., and Assad J.A.
Nature Neuroscience, 14: 1075-1079, 2011.
A Proposed Common Neural Mechanism for Categorization and Perceptual Decisions
Freedman D.J. and Assad J.A.
Nature Neuroscience, 14: 143-146, 2011.
Science Life article by Robert Mitchum
Pre-2010
Distinct Encoding of Spatial and Non-Spatial Factors in Parietal Cortex
Freedman D.J. and Assad J.A.
Journal of Neuroscience, 29: 5671-5680, 2009.
Dynamic Population Coding of Category Information in the Inferior Temporal Cortex and Prefrontal Cortex
Meyers E.M, Freedman D.J., Kreiman G., Miller E.K, and Poggio T.
Journal of Neurophysiology, 100: 1407-1419, 2008.
Neuronal Mechanisms of Visual Categorization and Category Learning
Freedman D.J.
In: The Neuroscience of Rule-Guided Behavior.
Wallis J.D. and Bunge S. (eds.). Oxford University Press, 2007.
Experience-Dependent Representation of Visual Categories in Parietal Cortex
Freedman D.J. and Assad J.A.
Nature, 443: 85-88, 2006.
News and Views by Vincent Ferrera and Jack Grinband
Nature Abstractions interview with David Freedman
Experience-Dependent Sharpening of Visual Shape Selectivity in Inferior Temporal Cortex
Freedman D.J., Riesenhuber M., Poggio T., and Miller E.K.
Cerebral Cortex, 16: 1631-1644, 2006.
Posterior Parietal Cortex: Space…and Beyond
Freedman D.J.
Neuron, 42: 881-883, 2004. (Preview)
A Comparison of Primate Prefrontal and Inferior Temporal Cortex During Visual Categorization
Freedman D.J., Riesenhuber M., Poggio T., and Miller E.K.
Journal of Neuroscience, 23: 5235-5246, 2003.
Neural Correlates of Categories and Concepts
Miller E.K., Nieder A., Freedman D.J., Wallis J.D.
Current Opinion in Neurobiology, 13:2:198-203, 2003.
Representation of the Quantity of Visual Items in the Primate Prefrontal Cortex
Nieder A., Freedman D.J., and Miller E.K.
Science, 297: 1708-1711, 2002.
The Prefrontal Cortex: Categories, Concepts, and Cognition
Miller E.K., Freedman D.J., Wallis J.D.
Philosophical Transactions of the Royal Society London: Biological Sciences, 357: 1123-1136, 2002.
Visual Categorization and the Primate Prefrontal Cortex: Neurophysiology and Behavior
Freedman D.J., Riesenhuber M., Poggio T., and Miller E.K.
Journal of Neurophysiology, 88: 929-941, 2002.
Categorical Representation of Visual Stimuli in the Primate Prefrontal Cortex
Freedman D.J., Riesenhuber M., Poggio T., and Miller E.K.
Science, 291: 312-316, 2001.